The Coxsackie viruses.

Coxsackie is a village on the banks of the Hudson River in upper New York State. In the course of investigating an outbreak of poliomyelitis there, Dalldorf and Sickles (1948) isolated a hitherto unrecognized filterable agent from the faeces of two children with lower limb paralysis. Neutralizing antibodies for this new virus appeared in the blood of both patients during convalescence. Attempts to isolate the poliomyelitis virus in rhesus monkeys were unsuccessful, but paralysis was induced in newborn suckling mice, although not in mice over twelve days old. This discovery heralded the advent of a new family of Coxsackie viruses.